the staff of the Ridgewood blog
Ridgewood NJ, having only been on the global radar since late November, early analysis around the world regarding the Omicron variant of concern (VOC) is providing insight into its characteristics and risks. Some preliminary laboratory analyses suggest that the Omicron variant could exhibit some resistance to SARS-CoV-2 vaccines. One study conducted by researchers in Germany (preprint) found that blood serum collected from fully vaccinated individuals had reduced efficacy in neutralizing the Omicron variant. The researchers tested sera from a variety of vaccinated patients, including those who received the Moderna, Pfizer-BioNTech, and AstraZeneca-Oxford vaccines, including some with heterologous combinations and some who received booster doses. The researchers observed reductions in neutralizing capacity on the order of 10-30 times, compared to the Delta variant. Additionally, sera from participants who received a heterologous combination of the AstraZeneca-Oxford and Pfizer-BioNTech vaccines exhibited “no efficacy against Omicron.” Preliminary findings from studies conducted by researchers in South Africa and Sweden (both preprint) are similar.
