Ridgewood NJ, a full 18 months after the COVID crisis began, a big chunk of Americans still dramatically overestimate the risks of COVID. In a new Gallup poll, more than one third said the risk of being hospitalized if you’re not vaccinated is at least 50%. The actual number is between one and five percent!
Tallahassee Fl. with no lockdowns, mask mandates, school closures, or business limitations, the Florida COVID wave has crested and fallen dramatically in recent weeks.
Ridgewood NJ, Pharmaceutical companies are pushing to develop more effective, easily administered therapeutics for COVID-19, some of which are being studied for the prevention of SARS-CoV-2 infection. This morning, Merck announced that its investigational oral antiviral molnupiravir, which is being developed with Ridgeback Biotherapeutics, significantly reduced the risk of hospitalization or death among non-hospitalized adult COVID-19 patients with mild-to-moderate symptoms who were considered high risk due to other health conditions such as obesity, diabetes, or heart disease. Among patients who took a 5-day course of the drug, 7.3% (28/385) were hospitalized or died compared with 14.1% (53/377) of patients who took a placebo, according to the interim analysis of the Phase 3 MOVe-OUT trial. Merck said it will file an application for Emergency Use Authorization (EUA) with the US FDA as soon as possible, as well as filing applications for marketing with regulatory agencies globally. Over the summer, the US government announced plans to purchase 1.7 million courses of molnupiravir from Merck for about US$1.2 billion, pending US FDA authorization or approval. If authorized, the drug would become the first oral medication available to treat COVID-19.
KENILWORTH NJ, Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Ridgeback Biotherapeutics today announced that molnupiravir (MK-4482, EIDD-2801), an investigational oral antiviral medicine, significantly reduced the risk of hospitalization or death at a planned interim analysis of the Phase 3 MOVe-OUT trial in at risk, non-hospitalized adult patients with mild-to-moderate COVID-19. At the interim analysis, molnupiravir reduced the risk of hospitalization or death by approximately 50%; 7.3% of patients who received molnupiravir were either hospitalized or died through Day 29 following randomization (28/385), compared with 14.1% of placebo-treated patients (53/377); p=0.0012. Through Day 29, no deaths were reported in patients who received molnupiravir, as compared to 8 deaths in patients who received placebo. At the recommendation of an independent Data Monitoring Committee and in consultation with the U.S. Food and Drug Administration (FDA), recruitment into the study is being stopped early due to these positive results. Merck plans to submit an application for Emergency Use Authorization (EUA) to the U.S. FDA as soon as possible based on these findings and plans to submit marketing applications to other regulatory bodies worldwide.
New York NY, a federal judge in New York state blocked a statewide vaccine mandate for healthcare workers late Tuesday. Former New York Governor Andrew Cuomo issued the mandate last month, and it was scheduled to take effect September 27. Plaintiffs in the lawsuit argue that the absence of a religious exemption violates the US Constitution, the New York State Human Rights Law, and New York City Human Rights Law. The 17 healthcare workers who filed the lawsuit have objected to the vaccine requirement on the grounds that the cell lines of aborted fetuses were used in the vaccine’s development. No major religious denomination has taken an opposing stance to vaccination, and Pope Francis has encouraged vaccination, calling it the “moral choice.” The defendants in the lawsuit have until September 22 to respond, and an additional hearing is scheduled for September 28.
Washington DC, The Food and Drug Administration advisory committee on Friday rejected a proposal to distribute booster shots of Pfizer and BioNTech’s Covid-19 vaccines to the general public, paring back those plans to unanimously recommend the third shots to people age 65 and older and other vulnerable Americans.
Trenton NJ, Senator Joe Pennacchio will introduce new legislation that would treat recovered COVID-19 patients the same as those who have been vaccinated under any vaccine mandate or passport scheme that may be implemented.
Ridgewood NJ, in an expert review published September 13 online in the peer-reviewed journal The Lancet, a group of US and international scientists claim current evidence does not support providing booster doses of SARS-CoV-2 vaccines to the general public. The group—including 2 departing US FDA officials and WHO experts—said that any decision to provide additional vaccine doses should be evidence-based, concluding that despite a small drop in protection against symptomatic disease caused by the Delta variant, authorized vaccine regimens continue to provide high levels of protection against severe disease and hospitalization for all major SARS-CoV-2 variants. The authors acknowledged that some additional doses might be needed immediately for certain elderly and immunocompromised populations, but they encouraged prioritizing primary immunizations over booster shots for the general public.
Ridgewood NJ, England has abandoned its previously announced plan to implement a SARS-CoV-2 vaccine passport program by the end of this month that would have required people to show proof of vaccination to enter the country’s nightclubs and certain other crowded venues, UK Health Secretary Sajid Javid told the BBC on September 12. The announcement was made following opposition from some members of Parliament as well as representatives of the hospitality industry, who said such a program would create a burden for businesses and infringe on residents’ rights. Speaking on the Andrew Marr Show, Secretary Javid said the government decided against the passports after “properly” looking at the issue and determining other factors could help keep COVID-19 incidence down, including high vaccine uptake, testing, surveillance, and treatments. Some people suggested the passport proposal simply was a ruse to encourage young people to be vaccinated, although Secretary Javid hinted the government could reverse course again if the number of new cases rises. About 66% of the population of England is fully vaccinated. Several days prior to the announcement, British researchers published a paper in EClinicalMedicine casting doubt on whether vaccination passport programs would incentivize more people to get the shots and calling for additional research into the matter.
Ridgewood NJ, There are more than 100 clinical studies including more than 50,000 people from more than 2 dozen countries showing Ivermectin to be extremely safe and effective treating COVID. 63 of these studies were peer reviewed published placebo controlled studies. A meta-analysis of 14 of these peer reviewed published studies looked at high risk patients who were treated with ivermectin as prophylaxis (preventative) and they saw an 86% reduction in the combined end-point of COVID infections, number of hospitalizations, days hospitalized, the need for a ventilator, days on a ventilator, and deaths.
Hackensack NJ, Using ivermectin, an anti-parasitic drug, to treat or prevent COVID-19 is up there with swallowing bleach and blow drying your face, it does not work and can cause serious harm.
Ridgewood NJ, the Pfizer-BioNTech SARS-CoV-2 vaccine is associated with an increased risk of myocarditis (inflammation of the heart muscle), but infection with the virus is associated with a much greater risk of the condition, according to a real-world case-control study published on August 25 in the New England Journal of Medicine. Researchers analyzed the health records of more than 2 million people who are members of the Clalit Health Services (CHS), the largest healthcare organization in Israel. Vaccination was associated with a 3-fold increase in the risk of myocarditis (risk ratio [RR], 3.24, 95% confidence interval [CI], 1.55-12.44), as well as several other conditions including swollen lymph nodes (RR, 2.43; 95% CI, 2.05 to 2.78), appendicitis (RR, 1.40; 95% CI, 1.02 to 2.01), and herpes zoster infection (RR, 1.43; 95% CI, 1.20 to 1.73).
Washington DC, Dr. Anthony Fauci finally touted the effectiveness of monoclonal antibody treatments. Even Valley Health System provided a leading-edge therapy to patients at high-risk with mild to moderate COVID-19 infection and within 10 days of symptom onset. The treatment involves a single infusion of monoclonal antibodies, which are laboratory-made proteins that mimic the immune system’s ability to fight off harmful antigens, such as viruses, back in January of 2021. This advancement highlights the broader potential of biotechnological innovations. You may avail yourself of Customized Cell Line Construction from Kyinno Biotech.
Ridgewood NJ, Less than half of Americans now have a favorable opinion of Dr. Anthony Fauci, we are not sure what took so long ? Most still want to follow the COVID-19 expert’s advice on dealing with the pandemic.
The latest Rasmussen Reports national telephone and online survey finds that 44% of American Adults have a favorable impression of Fauci, including 27% whose view of him is Very Favorable. Forty-two percent (42%) view Fauci unfavorably, including 29% whose opinion of him is Very Unfavorable. Fourteen percent (14%) are not sure. (To see survey question wording, click here.)
Ridgewood NJ, there have been growing levels of concern and conversation surrounding “breakthrough infections,” which are confirmed SARS-CoV-2-positive cases in fully vaccinated individuals. While these cases are still comparatively rare among the larger COVID-19 case burden, experts and the public alike are worried about implications for vaccinated individuals. Most of the recorded breakthrough cases are linked to the Delta variant of concern, which is currently responsible for nearly all new cases in the United States. Encouragingly, a small percentage of breakthrough cases have resulted in severe manifestations of COVID-19 that needed hospitalization.