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Pfizer-BioNTech SARS-CoV-2 vaccine is associated with an increased risk of myocarditis

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the staff of the Ridgewood blog
Ridgewood NJ, the Pfizer-BioNTech SARS-CoV-2 vaccine is associated with an increased risk of myocarditis (inflammation of the heart muscle), but infection with the virus is associated with a much greater risk of the condition, according to a real-world case-control study published on August 25 in the New England Journal of Medicine. Researchers analyzed the health records of more than 2 million people who are members of the Clalit Health Services (CHS), the largest healthcare organization in Israel. Vaccination was associated with a 3-fold increase in the risk of myocarditis (risk ratio [RR], 3.24, 95% confidence interval [CI], 1.55-12.44), as well as several other conditions including swollen lymph nodes (RR, 2.43; 95% CI, 2.05 to 2.78), appendicitis (RR, 1.40; 95% CI, 1.02 to 2.01), and herpes zoster infection (RR, 1.43; 95% CI, 1.20 to 1.73).

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Delivery for Pfizer/BioNTech COVID-vaccine has Proven Challenging

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the staff of the Ridgewood blog

Ridgewood NJ, according to Johns Hopkins Center for Health Security the complex cold chain logistics required for the Pfizer/BioNTech SARS-CoV-2 vaccine have proven challenging in certain settings in the first week of the United States’ vaccination operations. While the principal concern in planning for the distribution of this vaccine has been ensuring that the vaccine remains cold enough, incidents in Alabama and California demonstrate that allowing the vaccines to get too cold could also be a risk. Reportedly, several thousand doses of the vaccine shipped to Alabama and California were exposed to temperatures below the acceptable threshold of -112°F (-80°C) while en route to the state distribution centers. The issue was identified before the doses were unloaded from the truck, and the doses were “quarantined” while Pfizer and federal health and regulatory officials determine whether they remain viable. Pfizer shipped replacement doses to both states. These incidents highlight how challenges in implementing cold chain logistics can lead to wastage of vaccine doses, which could be particularly impactful when supply and production capacity are limited.

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