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New CRISPR-based Tool Can Insert Large DNA Sequences Into Desired Cells

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the staff of the Ridgewood blog

Ridgewood NJ, MIT researchers have designed a new tool that can cut and replace genes safelt and efficiently. PASTE (Programmable Addition via Site-specific Targeting Elements) can deliver genes as long as 36,000 DNA base pairs to several types of human cells. It works by combining the precise targeting of CRISPR-Cas9 with enzymes that viruses use to insert genetic material into bacterial genomes. In tests, the researchers were able to insert genes with a success rate ranging from 5% to 60% with very few unwanted changes.

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