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Vaccine Makers are Working to Determine how well the Current Vaccine Formulations hold up Against Omicron

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the staff of the Ridgewood blog
Ridgewood NJ, the emergence of the Omicron SARS-CoV-2 variant in southern Africa has vaccine manufacturers discussing vaccine effectiveness and the possibility of updating vaccines to make them variant-specific. Omicron has around 50 mutations, and more than 30 of the mutations are located on the viral spike protein that is responsible for entry into host cells. The SARS-CoV-2 spike protein also is one of the primary antibody targets for the immune system. According to some analysis, most of the antibody target sites on Omicron’s spike protein are mutated, and several of those differences could indicate that Omicron is capable of escaping current vaccine formulations. A subset of Omicron’s spike mutations have been previously reported in the Beta and Delta variants, but 26 spike mutations are believed to be unique. Scientists are anticipating a decrease in antibody neutralization of the virus, and doctors in South Africa are reporting reinfections in patients who have already recovered from COVID-19.

Pfizer-BioNTech, Moderna, AstraZeneca, and J&J-Janssen—as well as laboratories worldwide—are working to determine how well the current vaccine formulations hold up against Omicron. Data from these experiments are expected within the next 2 weeks. Pfizer-BioNTech and Moderna said they could have variant-specific booster doses ready to ship in about 3 months. It will likely take several weeks before we know if current vaccine formulations are effective against Omicron, but they are expected to continue to help reduce the risk of hospitalization and death due to COVID-19. As a result, primary vaccination and booster doses are recommended for every person who is eligible to receive one.

2 thoughts on “Vaccine Makers are Working to Determine how well the Current Vaccine Formulations hold up Against Omicron

  1. The South African doctor who discovered the variant already said the symptoms are very mild and short lived and she was shocked at the panic displayed by Britian and the USA.

    But leave it to Dr. Fake Fauci to invoke fear and panic in the citizenry. Cannot believe anything this Democrat political screw up says.

    Here come more useless mask mandates and pressure to get vaccine boosters although Fauci says the new variant escapes the vaccine.

    So…the new variant breaks through the vaccine so get the vaccine. Dumb.

    Insanity.

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  2. The “vaccine” already doesn’t work on any covid, so doubtful that it will work with “omicron”…

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